Light-carved 'nano-volcanoes' hold promise for drug delivery
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| Researchers from NC State University are able to carve nanoscale "volcanoes" by scattering light through a polymer "crystal ball" onto a photo-reactive thin film. The structures hold promise for new drug-delivery technologies. Credit: Chih-Hao Chang, North Carolina State University |
"We can control the pattern of light by changing the diameter of the nanoparticle spheres, or by changing the wavelength -- or color -- of the light that we shine through the spheres," says Xu Zhang, a doctoral student in mechanical and aerospace engineering at NC State and lead author of a paper describing the work. "That means we can control the shape and geometry of these structures, such as how big the cavity of the nano-volcano will be."
The researchers developed a highly accurate computer model that predicts the shape and dimensions of the nano-volcanoes based on the diameter of the nanoscale sphere and the wavelength of light.
Because these structures have precisely measured hollow cores, and precisely measured openings at the "mouth" of the nano-volcanoes, they are good candidates for drug-delivery mechanisms. The size of the core would allow users to control the amount of the drug a nano-volcano would store, while the size of the opening at the top of the nano-volcano could be used to regulate the drug's release.
"The materials used in this process are relatively inexpensive, and the process can be easily scaled up," says Dr. Chih-Hao Chang, an assistant professor of mechanical and aerospace engineering at NC State and co-author of the paper. "In addition, we can produce the nano-volcanoes in a uniformly patterned array, which may also be useful for controlling drug delivery."
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| NC State University researchers have created nanoscale "volcanoes" that can then be packed with precise amounts of other materials, including drugs. The approach holds promise for drug-delivery systems. Credit: Chih-Hao Chang, North Carolina State University |
Chang's team is now working to improve its understanding of the release rate from the nano-volcanoes, such as how quickly nanoparticles of different sizes will "escape" from nano-volcanoes with different-sized mouths. "That's essential information for drug-delivery applications," Chang says.
"It's exciting to take our understanding of how light scatters by particles and apply it to nanolithography in order to come up with something that could actually help people."
The paper, "Three-Dimensional Nanolithography Using Light Scattering from Colloidal Particles," was published online June 12 in ACS Nano. Lead author of the paper is NC State Ph.D. student Xu Zhang. Co-authors are Chang and NC State master's student Jonathan Elek. The research was supported by a NASA Early Career Faculty Award and the National Science Foundation's ASSIST Engineering Research Center at NC State.
Source: North Carolina State University
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on Saturday, June 15, 2013.
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